| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SACE_4608 | ilvB | SACE_4608 | SACE_0604 | Probable 3-isopropylmalate dehydrogenase. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.958 |
| SACE_4608 | ilvC | SACE_4608 | SACE_6157 | Probable 3-isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.861 |
| SACE_4608 | ilvD | SACE_4608 | SACE_1280 | Probable 3-isopropylmalate dehydrogenase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.740 |
| SACE_4608 | ilvN | SACE_4608 | SACE_6158 | Probable 3-isopropylmalate dehydrogenase. | Acetolactate synthase small subunit. | 0.977 |
| SACE_4608 | korA | SACE_4608 | SACE_3927 | Probable 3-isopropylmalate dehydrogenase. | 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. | 0.911 |
| SACE_4608 | leuB1 | SACE_4608 | SACE_3495 | Probable 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydrogenase. | 0.904 |
| ilvA | ilvA-2 | SACE_0904 | SACE_4356 | Putative threonine dehydratase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.920 |
| ilvA | ilvB | SACE_0904 | SACE_0604 | Putative threonine dehydratase. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.974 |
| ilvA | ilvC | SACE_0904 | SACE_6157 | Putative threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.861 |
| ilvA | ilvD | SACE_0904 | SACE_1280 | Putative threonine dehydratase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.853 |
| ilvA | ilvN | SACE_0904 | SACE_6158 | Putative threonine dehydratase. | Acetolactate synthase small subunit. | 0.989 |
| ilvA | korA | SACE_0904 | SACE_3927 | Putative threonine dehydratase. | 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. | 0.421 |
| ilvA | leuB | SACE_0904 | SACE_3196 | Putative threonine dehydratase. | 3-isopropylmalate dehydrogenase. | 0.976 |
| ilvA | leuB-2 | SACE_0904 | SACE_6154 | Putative threonine dehydratase. | Beta-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.972 |
| ilvA-2 | ilvA | SACE_4356 | SACE_0904 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative threonine dehydratase. | 0.920 |
| ilvA-2 | ilvB | SACE_4356 | SACE_0604 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.977 |
| ilvA-2 | ilvC | SACE_4356 | SACE_6157 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.832 |
| ilvA-2 | ilvD | SACE_4356 | SACE_1280 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.870 |
| ilvA-2 | ilvN | SACE_4356 | SACE_6158 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase small subunit. | 0.986 |
| ilvA-2 | leuB | SACE_4356 | SACE_3196 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase. | 0.977 |
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