Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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eryCIErythromycin biosynthesis transaminase EryCI; Sensor protein that transfers the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of erythromycin biosynthesis genes; Belongs to the DegT/DnrJ/EryC1 family. (366 aa)    
Predicted Functional Partners:
eryCVI
TDP-desosamine-N-dimethyltransferase.
  
 
 0.944
eryCV
EryCV NDP-4,6-dideoxyhexose 3,4-enoyl reductase.
 
 
 0.922
SACE_3203
Putative UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
  
 0.786
SACE_3920
UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
  
 0.777
ermE
N-6-aminoadenine-N-methyltransferase, erythromycinresistance; This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
     
 0.754
SACE_3224
Non-ribosomal peptide synthetase modules.
  
 
 0.677
rfbA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
 
  
 0.620
SACE_3176
Undecaprenyl-phosphate galactose phosphotransferase.
  
 0.588
SACE_0104
Glycosyl transferase.
  
  
 0.570
eryBIV
dTDP-4-keto-6-deoxy-L-hexose 4-reductase.
 
  
 0.561
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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