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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SACE_0997Response regulator, two-component system. (222 aa)    
Predicted Functional Partners:
SACE_0998
Probable two-component sensor kinase.
 
 
 0.977
SACE_3490
Sensor histidine kinase/response regulator.
  
 
 0.878
cutS
Two-component sensor (kinase).
 
 
 0.862
phoR
phoR-putative two-component system sensor kinase.
 
 
 0.847
SACE_6966
Putative two-component system sensor kinase.
 
 0.837
SACE_0265
Two component system histidine kinase.
 
 0.835
SACE_4790
Two-component system sensor kinase.
 
 
 0.830
SACE_5293
Putative two-component system sensor kinase.
 
 
 0.830
SACE_2832
Two-component system sensor kinase.
 
 
 0.828
SACE_3344
Two-component system sensor kinase.
 
 0.822
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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