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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
echA21Putative enoyl-CoA hydratase/isomerase family protein. (257 aa)    
Predicted Functional Partners:
accD1
propionyl-CoA carboxylase, beta subunit.
 
 0.933
hmgL
hydroxymethylglutaryl-CoA lyase.
 
 0.928
SACE_3041
Possible hydroxymethylglutaryl-CoA lyase.
 
 0.922
SACE_4360
hydroxymethylglutaryl-CoA lyase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.920
SACE_3490
Sensor histidine kinase/response regulator.
   
 
 0.776
SACE_4572
Polyketide biosynthesis enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
 
   
 0.756
SACE_2875
Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004.
  
 
 0.635
manB
Phosphomannomutase.
      
 0.601
pks1-3
Modular polyketide synthase.
  
 0.600
SACE_0625
Drug resistance transporter, Bcr/CflA family.
      
 0.590
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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