Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SACE_3406Alcohol dehydrogenase, zinc-binding domain protein. (338 aa)    
Predicted Functional Partners:
SACE_4139
Type I modular polyketide synthase.
  
 
 0.760
SACE_5379
Putative phosphotransferase.
 
    0.661
eryAII
EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2.
  
 
 0.657
SACE_2875
Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004.
  
 
 0.622
katE
Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide.
  
 
 0.614
SACE_2744
Phosphotransferase.
 
    0.607
SACE_3735
Alcohol dehydrogenase, zinc-binding.
 
 
 0.583
SACE_2629
Modular ype I polyketide synthase.
  
 
 0.563
fadE31
Putative acyl-CoA dehydrogenase.
  
    0.534
SACE_3405
TetR-family transcriptional regulator.
       0.532
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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