Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SACE_4285AMP-dependent synthetase and ligase. (1260 aa)    
Predicted Functional Partners:
eryAII
EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2.
 
0.960
SACE_4138
Type I PKS modular polyketide synthas.
 0.957
SACE_2875
Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004.
 
0.956
SACE_4139
Type I modular polyketide synthase.
  
 0.949
eryAIII
EryAIII Erythromycin polyketide synthase modules 5 and 6.
 
0.940
SACE_2629
Modular ype I polyketide synthase.
0.940
pks1-3
Modular polyketide synthase.
  
 0.928
SACE_2630
Modular polyketide synthase.
 
0.925
SACE_4140
Type I modular polyketide synthase.
 
0.924
SACE_4286
Thioesterase.
 
  
 0.914
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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