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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acsA-4Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa)    
Predicted Functional Partners:
ackA
Acetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
 
 0.967
gltA-2
Citrate synthase; Belongs to the citrate synthase family.
  
 0.952
citA
Citrate synthase.
  
 0.945
aceB,
Malate synthase A; Belongs to the malate synthase family.
   
 0.944
aarC
acetyl-CoA hydrolase/transferase.
  
 0.930
korA
2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
 
 0.929
mmsA2
Methylmalonate-semialdehyde dehydrogenase (acylating).
   
 0.924
thcA
Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.
   
 0.924
thcA-2
Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.
   
 0.924
mmsA1
Methylmalonate-semialdehyde dehydrogenase (acylating).
   
 0.924
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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