node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | SACE_5759 | SACE_5776 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.993 |
hisA | hisC-1 | SACE_5759 | SACE_5777 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.973 |
hisA | hisC2 | SACE_5759 | SACE_0217 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Putative histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.845 |
hisA | hisC2-2 | SACE_5759 | SACE_4645 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Putative histidinol-phosphate aminotransferase. | 0.843 |
hisA | hisD | SACE_5759 | SACE_5778 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.968 |
hisA | hisD2 | SACE_5759 | SACE_3119 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.962 |
hisA | hisF | SACE_5759 | SACE_5756 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SACE_5759 | SACE_2238 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.987 |
hisA | hisH | SACE_5759 | SACE_5761 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase,amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SACE_5759 | SACE_5755 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | SACE_5776 | SACE_5759 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.993 |
hisB | hisC-1 | SACE_5776 | SACE_5777 | Imidazoleglycerol-phosphate dehydratase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisC2 | SACE_5776 | SACE_0217 | Imidazoleglycerol-phosphate dehydratase. | Putative histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.996 |
hisB | hisC2-2 | SACE_5776 | SACE_4645 | Imidazoleglycerol-phosphate dehydratase. | Putative histidinol-phosphate aminotransferase. | 0.986 |
hisB | hisD | SACE_5776 | SACE_5778 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisB | hisD2 | SACE_5776 | SACE_3119 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.982 |
hisB | hisF | SACE_5776 | SACE_5756 | Imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SACE_5776 | SACE_2238 | Imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.988 |
hisB | hisH | SACE_5776 | SACE_5761 | Imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol-phosphate synthase,amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | SACE_5776 | SACE_5755 | Imidazoleglycerol-phosphate dehydratase. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.983 |