node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SACE_2336 | dnaA | SACE_2336 | SACE_0001 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.564 |
SACE_2336 | dnaB | SACE_2336 | SACE_7347 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.779 |
SACE_2336 | dnaE | SACE_2336 | SACE_5815 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.901 |
SACE_2336 | dnaG | SACE_2336 | SACE_1506 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA primase (bacterial type); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.764 |
SACE_2336 | dnaN | SACE_2336 | SACE_0003 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.986 |
SACE_2336 | holB | SACE_2336 | SACE_0379 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA polymerase III, delta' subunit. | 0.983 |
SACE_2336 | nusG | SACE_2336 | SACE_6872 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | Putative transcription antitermination regulator; Participates in transcription elongation, termination and antitermination. | 0.680 |
SACE_2336 | recA | SACE_2336 | SACE_1736 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA recombination/repair; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.702 |
SACE_2336 | rpoA | SACE_2336 | SACE_6803 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.664 |
SACE_2336 | rpoC | SACE_2336 | SACE_6853 | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.766 |
dnaA | SACE_2336 | SACE_0001 | SACE_2336 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | 0.564 |
dnaA | dnaB | SACE_0001 | SACE_7347 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.962 |
dnaA | dnaE | SACE_0001 | SACE_5815 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.585 |
dnaA | dnaG | SACE_0001 | SACE_1506 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA primase (bacterial type); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.776 |
dnaA | dnaN | SACE_0001 | SACE_0003 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.996 |
dnaA | nusG | SACE_0001 | SACE_6872 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | Putative transcription antitermination regulator; Participates in transcription elongation, termination and antitermination. | 0.775 |
dnaA | recA | SACE_0001 | SACE_1736 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA recombination/repair; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.870 |
dnaA | rpoA | SACE_0001 | SACE_6803 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.588 |
dnaA | rpoC | SACE_0001 | SACE_6853 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.722 |
dnaB | SACE_2336 | SACE_7347 | SACE_2336 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III alpha subunit (fragment); C-terminal half is missing, also contains mutations in the N terminal part, which probably inactivates it. | 0.779 |