STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflBPyruvate formate lyase I, induced anaerobically. (760 aa)    
Predicted Functional Partners:
pflA
Pyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
  
 0.991
adhE
Multifunctional: acetaldehyde-CoA dehydrogenase (N-terminal); iron-dependent alcohol dehydrogenase (C-terminal); pyruvate-formate lyase deactivase.
 
 
 0.970
XNC1_1758
Putative Pyruvate dehydrogenase (acetyl-transferring).
   
 
 0.969
maeB
Putative bifunctional: malic oxidoreductase (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 
 0.952
pta
Phosphotransacetylase (phosphate acetyltransferase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.946
sfcA
NAD-linked malate dehydrogenase.
   
 
 0.925
aceF
Pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
   
 
 0.921
ldhA
Fermentative D-lactate dehydrogenase, NAD-dependent; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.917
pykF
Pyruvate kinase I (formerly F), fructose-stimulated.
   
 
 0.916
pykA
Pyruvate kinase II, glucose-stimulated; Belongs to the pyruvate kinase family.
   
 
 0.916
Your Current Organism:
Xenorhabdus nematophila
NCBI taxonomy Id: 406817
Other names: X. nematophila ATCC 19061, Xenorhabdus nematophila ATCC 19061, Xenorhabdus nematophila str. ATCC 19061, Xenorhabdus nematophila strain ATCC 19061
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