node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMK17587.1 | AMK17891.1 | K663_06010 | K663_07550 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | 0.900 |
AMK17587.1 | AMK19056.1 | K663_06010 | K663_13390 | COG0518 GMP synthase - Glutamine amidotransferase domain. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.908 |
AMK17587.1 | AMK19460.1 | K663_06010 | K663_15410 | COG0518 GMP synthase - Glutamine amidotransferase domain. | COG0067 Glutamate synthase domain 1. | 0.590 |
AMK17587.1 | apt | K663_06010 | K663_12950 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.936 |
AMK17587.1 | gmk | K663_06010 | K663_10075 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.920 |
AMK17587.1 | guaA | K663_06010 | K663_15375 | COG0518 GMP synthase - Glutamine amidotransferase domain. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.912 |
AMK17587.1 | guaB | K663_06010 | K663_04205 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.991 |
AMK17587.1 | pheT | K663_06010 | K663_00520 | COG0518 GMP synthase - Glutamine amidotransferase domain. | phenylalanyl-tRNA ligase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.587 |
AMK17587.1 | rplK | K663_06010 | K663_11855 | COG0518 GMP synthase - Glutamine amidotransferase domain. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.631 |
AMK17587.1 | surE | K663_06010 | K663_11135 | COG0518 GMP synthase - Glutamine amidotransferase domain. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
AMK17891.1 | AMK17587.1 | K663_07550 | K663_06010 | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.900 |
AMK17891.1 | apt | K663_07550 | K663_12950 | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.902 |
AMK17891.1 | guaA | K663_07550 | K663_15375 | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.902 |
AMK17891.1 | pheT | K663_07550 | K663_00520 | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | phenylalanyl-tRNA ligase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.507 |
AMK17891.1 | surE | K663_07550 | K663_11135 | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.903 |
AMK19056.1 | AMK17587.1 | K663_13390 | K663_06010 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.908 |
AMK19056.1 | guaA | K663_13390 | K663_15375 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.977 |
AMK19056.1 | guaB | K663_13390 | K663_04205 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.955 |
AMK19056.1 | pheT | K663_13390 | K663_00520 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | phenylalanyl-tRNA ligase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.405 |
AMK19056.1 | surE | K663_13390 | K663_11135 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.903 |