node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMK17067.1 | AMK17928.1 | K663_03390 | K663_07735 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.673 |
AMK17067.1 | AMK18055.1 | K663_03390 | K663_08370 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. | 0.943 |
AMK17067.1 | leuA | K663_03390 | K663_06965 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.929 |
AMK17928.1 | AMK17067.1 | K663_07735 | K663_03390 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.673 |
AMK17928.1 | AMK18055.1 | K663_07735 | K663_08370 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. | 0.943 |
AMK17928.1 | leuA | K663_07735 | K663_06965 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.929 |
AMK18055.1 | AMK17067.1 | K663_08370 | K663_03390 | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.943 |
AMK18055.1 | AMK17928.1 | K663_08370 | K663_07735 | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.943 |
AMK18055.1 | leuA | K663_08370 | K663_06965 | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; COG2030 Acyl dehydratase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.952 |
AMK19484.1 | ilvC | K663_15530 | K663_06980 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.551 |
AMK19484.1 | ilvD | K663_15530 | K663_07895 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.962 |
AMK19484.1 | ilvD-2 | K663_15530 | K663_09725 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.962 |
AMK19484.1 | ilvH | K663_15530 | K663_06985 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.557 |
AMK19484.1 | leuA | K663_15530 | K663_06965 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.986 |
AMK19484.1 | leuC | K663_15530 | K663_13425 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.561 |
AMK19484.1 | leuD | K663_15530 | K663_13420 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.400 |
ilvC | AMK19484.1 | K663_06980 | K663_15530 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.551 |
ilvC | ilvD | K663_06980 | K663_07895 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.992 |
ilvC | ilvD-2 | K663_06980 | K663_09725 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.986 |
ilvC | ilvH | K663_06980 | K663_06985 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.999 |