STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEM26261.12-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (447 aa)    
Predicted Functional Partners:
SEK34007.1
Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component.
 0.999
SEL67761.1
Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
SEM07121.1
2-oxoglutarate dehydrogenase E1 component.
 0.999
SEK57366.1
Dihydrolipoamide dehydrogenase.
 0.998
SEK89241.1
Dihydrolipoamide dehydrogenase.
 0.998
SEM06956.1
Dihydrolipoamide dehydrogenase.
 0.998
SEK34701.1
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component.
 0.997
pdhA
Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.997
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.990
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.984
Your Current Organism:
Pseudosphingobacterium domesticum
NCBI taxonomy Id: 407022
Other names: CCUG 54353, DSM 18733, LMG 23837, LMG:23837, Olivibacter domesticus, P. domesticum, Pseudosphingobacterium domesticum Vaz-Moreira et al. 2007 emend. Hahnke et al. 2016, strain DC-186
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