node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKG72829.1 | AKG74607.1 | AAT16_00490 | AAT16_10645 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
AKG72829.1 | mqo | AAT16_00490 | AAT16_00870 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.800 |
AKG72829.1 | mqo-2 | AAT16_00490 | AAT16_12265 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.800 |
AKG74607.1 | AKG72829.1 | AAT16_10645 | AAT16_00490 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
AKG74607.1 | AKG74662.1 | AAT16_10645 | AAT16_10940 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.913 |
AKG74607.1 | AKG75303.1 | AAT16_10645 | AAT16_07625 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
AKG74607.1 | folD | AAT16_10645 | AAT16_05005 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.951 |
AKG74607.1 | folD-2 | AAT16_10645 | AAT16_10325 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
AKG74607.1 | gcvT | AAT16_10645 | AAT16_07105 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
AKG74607.1 | glyA | AAT16_10645 | AAT16_11715 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
AKG74607.1 | mqo | AAT16_10645 | AAT16_00870 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.815 |
AKG74607.1 | mqo-2 | AAT16_10645 | AAT16_12265 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Malate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.815 |
AKG74607.1 | purN | AAT16_10645 | AAT16_05050 | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.933 |
AKG74662.1 | AKG74607.1 | AAT16_10940 | AAT16_10645 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
AKG74662.1 | AKG75303.1 | AAT16_10940 | AAT16_07625 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.908 |
AKG74662.1 | gcvT | AAT16_10940 | AAT16_07105 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
AKG74662.1 | glyA | AAT16_10940 | AAT16_11715 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |
AKG74662.1 | purN | AAT16_10940 | AAT16_05050 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
AKG75303.1 | AKG74607.1 | AAT16_07625 | AAT16_10645 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formyltetrahydrofolate deformylase; Produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
AKG75303.1 | AKG74662.1 | AAT16_07625 | AAT16_10940 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.908 |