STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKG74730.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.584
gyrB-2
DNA gyrase subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily.
   
 
 0.584
fda
Fructose-1,6-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I fructose-bisphosphate aldolase family.
       0.503
AKG75352.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.485
AKG74729.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.485
AKG74728.1
C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.470
AKG74725.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.443
AKG74726.1
C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.443
AKG74727.1
C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.443
AKG74724.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.433
Your Current Organism:
Salinicoccus halodurans
NCBI taxonomy Id: 407035
Other names: CGMCC 1.6501, DSM 19336, S. halodurans, Salinicoccus halodurans Wang et al. 2008, Salinicoccus sp. W24, strain W24
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