node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDJ68294.1 | SDK23181.1 | SAMN05216243_0282 | SAMN05216243_2452 | Ribonuclease HI. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.597 |
SDJ68294.1 | rnhB | SAMN05216243_0282 | SAMN05216243_0533 | Ribonuclease HI. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.724 |
SDJ68294.1 | thyA | SAMN05216243_0282 | SAMN05216243_0290 | Ribonuclease HI. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.605 |
SDJ72749.1 | SDJ72765.1 | SAMN05216243_0531 | SAMN05216243_0532 | Flagellar biosynthesis protein. | Hypothetical protein. | 0.800 |
SDJ72749.1 | rnhB | SAMN05216243_0531 | SAMN05216243_0533 | Flagellar biosynthesis protein. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.852 |
SDJ72765.1 | SDJ72749.1 | SAMN05216243_0532 | SAMN05216243_0531 | Hypothetical protein. | Flagellar biosynthesis protein. | 0.800 |
SDJ72765.1 | acpP | SAMN05216243_0532 | SAMN05216243_0548 | Hypothetical protein. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.628 |
SDJ72765.1 | rnhB | SAMN05216243_0532 | SAMN05216243_0533 | Hypothetical protein. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.785 |
SDK16934.1 | rnhB | SAMN05216243_2143 | SAMN05216243_0533 | Phosphoglucomutase. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.855 |
SDK23181.1 | SDJ68294.1 | SAMN05216243_2452 | SAMN05216243_0282 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Ribonuclease HI. | 0.597 |
SDK23181.1 | acpP | SAMN05216243_2452 | SAMN05216243_0548 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.410 |
SDK23181.1 | rnhB | SAMN05216243_2452 | SAMN05216243_0533 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.928 |
SDK23181.1 | thyA | SAMN05216243_2452 | SAMN05216243_0290 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.835 |
SDK29153.1 | rnhB | SAMN05216243_2645 | SAMN05216243_0533 | Signal peptidase I; Belongs to the peptidase S26 family. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.734 |
acpP | SDJ72765.1 | SAMN05216243_0548 | SAMN05216243_0532 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Hypothetical protein. | 0.628 |
acpP | SDK23181.1 | SAMN05216243_0548 | SAMN05216243_2452 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.410 |
acpP | dnaJ | SAMN05216243_0548 | SAMN05216243_3466 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.936 |
acpP | rnhB | SAMN05216243_0548 | SAMN05216243_0533 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.758 |
dnaJ | acpP | SAMN05216243_3466 | SAMN05216243_0548 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.936 |
dnaJ | rnhB | SAMN05216243_3466 | SAMN05216243_0533 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.751 |