STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)    
Predicted Functional Partners:
SDK41812.1
Succinate dehydrogenase / fumarate reductase flavoprotein subunit.
 
 0.959
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.950
SDK26570.1
Arginase; Belongs to the arginase family.
 
   
 0.922
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.907
SDJ98981.1
FAD dependent oxidoreductase.
  
 0.889
SDK41785.1
Succinate dehydrogenase / fumarate reductase iron-sulfur subunit.
  
 0.888
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.877
SDK41827.1
Succinate dehydrogenase / fumarate reductase cytochrome b subunit.
   
 
 0.873
SDK42833.1
Citrate synthase; Belongs to the citrate synthase family.
   
 0.835
SDK43022.1
Malate dehydrogenase (oxaloacetate-decarboxylating).
  
 
 0.834
Your Current Organism:
Sediminibacillus albus
NCBI taxonomy Id: 407036
Other names: CGMCC 1.6502, DSM 19340, S. albus, Sediminibacillus albus Wang et al. 2009, Virgibacillus sp. NHBX5, strain NHBX5
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