node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIS54407.1 | fhs | SAMN05421795_101451 | SAMN05421795_101586 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.649 |
SIS54407.1 | fmt | SAMN05421795_101451 | SAMN05421795_108105 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.580 |
SIS54407.1 | folD | SAMN05421795_101451 | SAMN05421795_101585 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.962 |
SIS54407.1 | purH | SAMN05421795_101451 | SAMN05421795_102314 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | IMP cyclohydrolase. | 0.517 |
SIS54407.1 | purN | SAMN05421795_101451 | SAMN05421795_101193 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.909 |
SIS77271.1 | SIS77616.1 | SAMN05421795_104110 | SAMN05421795_104148 | Aminomethyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.951 |
SIS77271.1 | SIS80500.1 | SAMN05421795_104110 | SAMN05421795_105125 | Aminomethyltransferase. | Methylenetetrahydrofolate reductase (NADPH). | 0.905 |
SIS77271.1 | fhs | SAMN05421795_104110 | SAMN05421795_101586 | Aminomethyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.923 |
SIS77271.1 | fmt | SAMN05421795_104110 | SAMN05421795_108105 | Aminomethyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
SIS77271.1 | folD | SAMN05421795_104110 | SAMN05421795_101585 | Aminomethyltransferase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.978 |
SIS77271.1 | glyA | SAMN05421795_104110 | SAMN05421795_102631 | Aminomethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
SIS77271.1 | purH | SAMN05421795_104110 | SAMN05421795_102314 | Aminomethyltransferase. | IMP cyclohydrolase. | 0.920 |
SIS77271.1 | purN | SAMN05421795_104110 | SAMN05421795_101193 | Aminomethyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |
SIS77271.1 | purU | SAMN05421795_104110 | SAMN05421795_101101 | Aminomethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |
SIS77616.1 | SIS77271.1 | SAMN05421795_104148 | SAMN05421795_104110 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase. | 0.951 |
SIS77616.1 | SIS80500.1 | SAMN05421795_104148 | SAMN05421795_105125 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate reductase (NADPH). | 0.933 |
SIS77616.1 | fhs | SAMN05421795_104148 | SAMN05421795_101586 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.631 |
SIS77616.1 | fmt | SAMN05421795_104148 | SAMN05421795_108105 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.410 |
SIS77616.1 | folD | SAMN05421795_104148 | SAMN05421795_101585 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.948 |
SIS77616.1 | glyA | SAMN05421795_104148 | SAMN05421795_102631 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |