pfp protein (Thioploca ingrica) - STRING interaction network

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pfp

6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (422 aa)

Predicted Functional Partners:

pgi

0.985

THII_3338

0.960

THII_0785

0.933

THII_3057

0.928

THII_3339

0.926

THII_3035

0.918

THII_1873

0.903

THII_1874

0.902

eno

0.870

tpiA

0.840

Your Current Organism:

Thioploca ingrica

NCBI taxonomy Id: 40754
Other names: T. ingrica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
THII_0785	THII_1873	THII_0785	THII_1873	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Transketolase, N-terminal subunit.	0.917
THII_0785	THII_1874	THII_0785	THII_1874	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Transketolase, C-terminal subunit.	0.938
THII_0785	THII_3338	THII_0785	THII_3338	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Ketose-bisphosphate aldolase, class-II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.	0.966
THII_0785	THII_3339	THII_0785	THII_3339	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.961
THII_0785	eno	THII_0785	THII_3630	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.947
THII_0785	pfp	THII_0785	THII_0379	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.933
THII_0785	pgi	THII_0785	THII_1441	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.965
THII_0785	tpiA	THII_0785	THII_3402	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.976
THII_1873	THII_0785	THII_1873	THII_0785	Transketolase, N-terminal subunit.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.917
THII_1873	THII_1874	THII_1873	THII_1874	Transketolase, N-terminal subunit.	Transketolase, C-terminal subunit.	0.999
THII_1873	THII_3338	THII_1873	THII_3338	Transketolase, N-terminal subunit.	Ketose-bisphosphate aldolase, class-II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.	0.909
THII_1873	THII_3339	THII_1873	THII_3339	Transketolase, N-terminal subunit.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.807
THII_1873	eno	THII_1873	THII_3630	Transketolase, N-terminal subunit.	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.800
THII_1873	pfp	THII_1873	THII_0379	Transketolase, N-terminal subunit.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.903
THII_1873	pgi	THII_1873	THII_1441	Transketolase, N-terminal subunit.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.901
THII_1873	tpiA	THII_1873	THII_3402	Transketolase, N-terminal subunit.	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.907
THII_1874	THII_0785	THII_1874	THII_0785	Transketolase, C-terminal subunit.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.938
THII_1874	THII_1873	THII_1874	THII_1873	Transketolase, C-terminal subunit.	Transketolase, N-terminal subunit.	0.999
THII_1874	THII_3338	THII_1874	THII_3338	Transketolase, C-terminal subunit.	Ketose-bisphosphate aldolase, class-II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.	0.909
THII_1874	THII_3339	THII_1874	THII_3339	Transketolase, C-terminal subunit.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.804

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