| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| THII_0881 | THII_1235 | THII_0881 | THII_1235 | Muramoyltetrapeptide carboxypeptidase. | Glycosyl hydrolase. | 0.588 |
| THII_1235 | THII_0881 | THII_1235 | THII_0881 | Glycosyl hydrolase. | Muramoyltetrapeptide carboxypeptidase. | 0.588 |
| THII_1235 | THII_1236 | THII_1235 | THII_1236 | Glycosyl hydrolase. | Hypothetical protein. | 0.773 |
| THII_1235 | THII_3728 | THII_1235 | THII_3728 | Glycosyl hydrolase. | Glutamate synthase. | 0.510 |
| THII_1235 | THII_3947 | THII_1235 | THII_3947 | Glycosyl hydrolase. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.504 |
| THII_1235 | anmK | THII_1235 | THII_2132 | Glycosyl hydrolase. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.700 |
| THII_1235 | glmM | THII_1235 | THII_2844 | Glycosyl hydrolase. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.491 |
| THII_1235 | glmU | THII_1235 | THII_1765 | Glycosyl hydrolase. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.488 |
| THII_1235 | mpl | THII_1235 | THII_0694 | Glycosyl hydrolase. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.488 |
| THII_1235 | murA | THII_1235 | THII_0366 | Glycosyl hydrolase. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.510 |
| THII_1235 | pepA | THII_1235 | THII_1306 | Glycosyl hydrolase. | Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.699 |
| THII_1236 | THII_1235 | THII_1236 | THII_1235 | Hypothetical protein. | Glycosyl hydrolase. | 0.773 |
| THII_3728 | THII_1235 | THII_3728 | THII_1235 | Glutamate synthase. | Glycosyl hydrolase. | 0.510 |
| THII_3947 | THII_1235 | THII_3947 | THII_1235 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Glycosyl hydrolase. | 0.504 |
| THII_3947 | anmK | THII_3947 | THII_2132 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.671 |
| THII_3947 | mpl | THII_3947 | THII_0694 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.601 |
| anmK | THII_1235 | THII_2132 | THII_1235 | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Glycosyl hydrolase. | 0.700 |
| anmK | THII_3947 | THII_2132 | THII_3947 | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.671 |
| anmK | glmM | THII_2132 | THII_2844 | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.489 |
| anmK | glmU | THII_2132 | THII_1765 | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.493 |