| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| THII_0596 | THII_1513 | THII_0596 | THII_1513 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Haloacid dehalogenase superfamily enzyme, subfamily IA. | 0.939 |
| THII_0596 | THII_1773 | THII_0596 | THII_1773 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | 0.706 |
| THII_0596 | THII_2935 | THII_0596 | THII_2935 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin synthase alpha chain. | 0.999 |
| THII_0596 | ileS | THII_0596 | THII_1379 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.455 |
| THII_0596 | mnmA | THII_0596 | THII_2718 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.558 |
| THII_0596 | ribH | THII_0596 | THII_2756 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.995 |
| THII_1513 | THII_0596 | THII_1513 | THII_0596 | Haloacid dehalogenase superfamily enzyme, subfamily IA. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.939 |
| THII_1513 | THII_1773 | THII_1513 | THII_1773 | Haloacid dehalogenase superfamily enzyme, subfamily IA. | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | 0.909 |
| THII_1513 | THII_2935 | THII_1513 | THII_2935 | Haloacid dehalogenase superfamily enzyme, subfamily IA. | Riboflavin synthase alpha chain. | 0.903 |
| THII_1513 | ribH | THII_1513 | THII_2756 | Haloacid dehalogenase superfamily enzyme, subfamily IA. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.904 |
| THII_1773 | THII_0596 | THII_1773 | THII_0596 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.706 |
| THII_1773 | THII_1513 | THII_1773 | THII_1513 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | Haloacid dehalogenase superfamily enzyme, subfamily IA. | 0.909 |
| THII_1773 | THII_1774 | THII_1773 | THII_1774 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | Dynamin family protein. | 0.762 |
| THII_1773 | THII_2935 | THII_1773 | THII_2935 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | Riboflavin synthase alpha chain. | 0.934 |
| THII_1773 | cmk | THII_1773 | THII_0034 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | Cytidylate kinase. | 0.786 |
| THII_1773 | ileS | THII_1773 | THII_1379 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.751 |
| THII_1773 | mnmA | THII_1773 | THII_2718 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.710 |
| THII_1773 | murJ | THII_1773 | THII_1772 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | MviN-like protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.923 |
| THII_1773 | ribH | THII_1773 | THII_2756 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.856 |
| THII_1773 | truB | THII_1773 | THII_1179 | Riboflavin biosynthesis protein ribF; Belongs to the ribF family. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.959 |