THII_2219 protein (Thioploca ingrica) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

THII_2219

Polyketide biosynthesis protein pksG. (419 aa)

Predicted Functional Partners:

THII_0839

0.995

THII_2208

0.955

THII_2220

0.955

THII_2201

0.949

THII_2215

0.946

THII_2202

0.801

THII_2209

0.770

THII_1050

0.723

THII_2783

0.687

THII_3156

0.675

Your Current Organism:

Thioploca ingrica

NCBI taxonomy Id: 40754
Other names: T. ingrica

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
THII_0839	THII_2201	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.978
THII_0839	THII_2208	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Polyketide synthase.	0.579
THII_0839	THII_2215	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malonyl CoA-ACP transacylase.	0.453
THII_0839	THII_2219	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Polyketide biosynthesis protein pksG.	0.995
THII_0839	THII_2220	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Polyketide biosynthesis enoyl-CoA hydratase.	0.974
THII_1050	THII_2201	Amino acid adenylation enzyme/thioester reductase family protein.	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.999
THII_1050	THII_2202	Amino acid adenylation enzyme/thioester reductase family protein.	Polyketide synthase.	0.853
THII_1050	THII_2208	Amino acid adenylation enzyme/thioester reductase family protein.	Polyketide synthase.	0.999
THII_1050	THII_2209	Amino acid adenylation enzyme/thioester reductase family protein.	Polyketide synthase.	0.897
THII_1050	THII_2215	Amino acid adenylation enzyme/thioester reductase family protein.	Malonyl CoA-ACP transacylase.	0.997
THII_1050	THII_2219	Amino acid adenylation enzyme/thioester reductase family protein.	Polyketide biosynthesis protein pksG.	0.723
THII_1050	THII_2220	Amino acid adenylation enzyme/thioester reductase family protein.	Polyketide biosynthesis enoyl-CoA hydratase.	0.562
THII_1050	THII_2783	Amino acid adenylation enzyme/thioester reductase family protein.	tubC protein.	0.997
THII_1050	THII_3156	Amino acid adenylation enzyme/thioester reductase family protein.	Squalene/phytoene synthase.	0.473
THII_2201	THII_0839	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.978
THII_2201	THII_1050	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Amino acid adenylation enzyme/thioester reductase family protein.	0.999
THII_2201	THII_2202	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Polyketide synthase.	0.939
THII_2201	THII_2208	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Polyketide synthase.	0.999
THII_2201	THII_2209	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Polyketide synthase.	0.931
THII_2201	THII_2215	FkbH-like protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Malonyl CoA-ACP transacylase.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.826

expected number of edges:

12

PPI enrichment p-value:

1.85e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 82

2.23

4.13

2.29e-09

GO:0006412

Translation

7 of 363

1.65

2.66

4.73e-08

GO:0030490

Maturation of SSU-rRNA

4 of 67

2.14

2.6

5.68e-06

GO:0006364

rRNA processing

5 of 268

1.64

1.99

1.31e-05

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 52

2.13

1.86

0.00024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 183

1.95

3.84

5.95e-10

GO:0030515

snoRNA binding

2 of 23

2.3

0.92

0.0206

GO:0003723

RNA binding

5 of 763

1.18

0.85

0.0053

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

5 of 27

2.63

4.96

2.91e-10

GO:0015935

Small ribosomal subunit

6 of 59

2.37

4.94

8.00e-11

GO:0005840

Ribosome

7 of 202

1.91

3.83

2.91e-10

GO:1990904

Ribonucleoprotein complex

8 of 551

1.53

2.65

1.59e-09

GO:0030684

Preribosome

4 of 107

1.94

2.35

9.86e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10688

Cytosolic small ribosomal subunit, and Ribosomal protein S8

5 of 13

2.95

5.34

1.20e-10

CL:11902

Preribosome, small subunit precursor

3 of 5

3.14

3.45

5.25e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

7 of 217

1.87

3.81

1.81e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

8 of 182

2.01

4.81

1.23e-12

MAP-8868773

rRNA processing in the nucleus and cytosol

8 of 185

2.0

4.79

1.23e-12

MAP-72312

rRNA processing

8 of 188

1.99

4.76

1.23e-12

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

6 of 103

2.13

4.25

4.48e-10

MAP-72702

Ribosomal scanning and start codon recognition

6 of 124

2.05

3.96

1.10e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015935

Small ribosomal subunit

7 of 73

2.35

5.74

7.38e-13

GOCC:0022627

Cytosolic small ribosomal subunit

6 of 39

2.55

5.72

4.85e-12

GOCC:1990904

Ribonucleoprotein complex

9 of 532

1.59

3.18

1.42e-11

GOCC:0030684

Preribosome

3 of 83

1.92

1.62

0.00054

GOCC:0030688

Preribosome, small subunit precursor

2 of 14

2.52

1.5

0.0017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 107

2.18

5.19

2.26e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03719

Ribosomal protein S5, C-terminal domain

2 of 2

3.37

1.62

0.0012

PF00333

Ribosomal protein S5, N-terminal domain

2 of 2

3.37

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013810

Ribosomal protein S5, N-terminal

2 of 2

3.37

1.39

0.0032

IPR005324

Ribosomal protein S5, C-terminal

2 of 2

3.37

1.39

0.0032

IPR000851

Ribosomal protein S5

2 of 2

3.37

1.39

0.0032

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

2 of 19

2.39

0.85

0.0279

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