| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| THII_0594 | THII_2688 | THII_0594 | THII_2688 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Bifunctional deaminase-reductase domain-containing protein. | 0.546 |
| THII_0594 | thyA | THII_0594 | THII_0723 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.846 |
| THII_2688 | THII_0594 | THII_2688 | THII_0594 | Bifunctional deaminase-reductase domain-containing protein. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.546 |
| THII_2688 | THII_2689 | THII_2688 | THII_2689 | Bifunctional deaminase-reductase domain-containing protein. | 3-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.693 |
| THII_2688 | THII_2690 | THII_2688 | THII_2690 | Bifunctional deaminase-reductase domain-containing protein. | Hypothetical protein. | 0.498 |
| THII_2688 | THII_3387 | THII_2688 | THII_3387 | Bifunctional deaminase-reductase domain-containing protein. | Prephenate dehydratase. | 0.419 |
| THII_2688 | THII_3905 | THII_2688 | THII_3905 | Bifunctional deaminase-reductase domain-containing protein. | biotin-(acetyl-CoA carboxylase) ligase. | 0.582 |
| THII_2688 | clpX | THII_2688 | THII_0146 | Bifunctional deaminase-reductase domain-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.651 |
| THII_2688 | gcvH | THII_2688 | THII_2083 | Bifunctional deaminase-reductase domain-containing protein. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.518 |
| THII_2688 | gcvT | THII_2688 | THII_2082 | Bifunctional deaminase-reductase domain-containing protein. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.528 |
| THII_2688 | thyA | THII_2688 | THII_0723 | Bifunctional deaminase-reductase domain-containing protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.845 |
| THII_2689 | THII_2688 | THII_2689 | THII_2688 | 3-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Bifunctional deaminase-reductase domain-containing protein. | 0.693 |
| THII_2689 | THII_2690 | THII_2689 | THII_2690 | 3-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Hypothetical protein. | 0.550 |
| THII_2690 | THII_2688 | THII_2690 | THII_2688 | Hypothetical protein. | Bifunctional deaminase-reductase domain-containing protein. | 0.498 |
| THII_2690 | THII_2689 | THII_2690 | THII_2689 | Hypothetical protein. | 3-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.550 |
| THII_3387 | THII_2688 | THII_3387 | THII_2688 | Prephenate dehydratase. | Bifunctional deaminase-reductase domain-containing protein. | 0.419 |
| THII_3905 | THII_2688 | THII_3905 | THII_2688 | biotin-(acetyl-CoA carboxylase) ligase. | Bifunctional deaminase-reductase domain-containing protein. | 0.582 |
| THII_3905 | gcvH | THII_3905 | THII_2083 | biotin-(acetyl-CoA carboxylase) ligase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.493 |
| clpX | THII_2688 | THII_0146 | THII_2688 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Bifunctional deaminase-reductase domain-containing protein. | 0.651 |
| gcvH | THII_2688 | THII_2083 | THII_2688 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Bifunctional deaminase-reductase domain-containing protein. | 0.518 |