| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| THII_3299 | THII_3300 | THII_3299 | THII_3300 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | General secretion pathway protein F. | 0.773 |
| THII_3299 | THII_3301 | THII_3299 | THII_3301 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | Hypothetical protein. | 0.596 |
| THII_3299 | THII_3343 | THII_3299 | THII_3343 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.493 |
| THII_3299 | THII_3809 | THII_3299 | THII_3809 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobyrinic acid a,c-diamide synthase. | 0.936 |
| THII_3299 | cysG | THII_3299 | THII_0982 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.661 |
| THII_3299 | polA | THII_3299 | THII_1270 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.423 |
| THII_3300 | THII_3299 | THII_3300 | THII_3299 | General secretion pathway protein F. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.773 |
| THII_3300 | THII_3301 | THII_3300 | THII_3301 | General secretion pathway protein F. | Hypothetical protein. | 0.596 |
| THII_3301 | THII_3299 | THII_3301 | THII_3299 | Hypothetical protein. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.596 |
| THII_3301 | THII_3300 | THII_3301 | THII_3300 | Hypothetical protein. | General secretion pathway protein F. | 0.596 |
| THII_3343 | THII_3299 | THII_3343 | THII_3299 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.493 |
| THII_3343 | cysG | THII_3343 | THII_0982 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.678 |
| THII_3809 | THII_3299 | THII_3809 | THII_3299 | Cobyrinic acid a,c-diamide synthase. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.936 |
| THII_3809 | cysG | THII_3809 | THII_0982 | Cobyrinic acid a,c-diamide synthase. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.951 |
| cysG | THII_3299 | THII_0982 | THII_3299 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.661 |
| cysG | THII_3343 | THII_0982 | THII_3343 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.678 |
| cysG | THII_3809 | THII_0982 | THII_3809 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobyrinic acid a,c-diamide synthase. | 0.951 |
| polA | THII_3299 | THII_1270 | THII_3299 | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.423 |