| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| THII_1235 | THII_3947 | THII_1235 | THII_3947 | Glycosyl hydrolase. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.504 |
| THII_1235 | anmK | THII_1235 | THII_2132 | Glycosyl hydrolase. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.700 |
| THII_1235 | mpl | THII_1235 | THII_0694 | Glycosyl hydrolase. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.488 |
| THII_2352 | THII_3947 | THII_2352 | THII_3947 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.422 |
| THII_2366 | THII_3947 | THII_2366 | THII_3947 | Aminoglycoside phosphotransferase. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.466 |
| THII_2366 | mpl | THII_2366 | THII_0694 | Aminoglycoside phosphotransferase. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.457 |
| THII_3944 | THII_3946 | THII_3944 | THII_3946 | Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Hypothetical protein. | 0.596 |
| THII_3944 | THII_3947 | THII_3944 | THII_3947 | Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.422 |
| THII_3946 | THII_3944 | THII_3946 | THII_3944 | Hypothetical protein. | Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.596 |
| THII_3946 | THII_3947 | THII_3946 | THII_3947 | Hypothetical protein. | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | 0.501 |
| THII_3947 | THII_1235 | THII_3947 | THII_1235 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Glycosyl hydrolase. | 0.504 |
| THII_3947 | THII_2352 | THII_3947 | THII_2352 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.422 |
| THII_3947 | THII_2366 | THII_3947 | THII_2366 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Aminoglycoside phosphotransferase. | 0.466 |
| THII_3947 | THII_3944 | THII_3947 | THII_3944 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.422 |
| THII_3947 | THII_3946 | THII_3947 | THII_3946 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Hypothetical protein. | 0.501 |
| THII_3947 | anmK | THII_3947 | THII_2132 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.671 |
| THII_3947 | lapB | THII_3947 | THII_0037 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Heat shock protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. | 0.487 |
| THII_3947 | mpl | THII_3947 | THII_0694 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.601 |
| THII_3947 | mrdA | THII_3947 | THII_3515 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.467 |
| THII_3947 | zapD | THII_3947 | THII_1982 | N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD. | Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.417 |