X975_17565 protein (Stegodyphus mimosarum) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

X975_17565

Ubiquitin carboxyl-terminal hydrolase. (493 aa)

Predicted Functional Partners:

X975_07424

0.999

X975_10700

0.999

X975_00332

0.999

X975_05717

0.999

X975_06809

0.999

X975_11669

0.999

X975_26864

0.998

X975_22663

0.998

X975_24776

0.998

X975_01408

0.998

Your Current Organism:

Stegodyphus mimosarum

NCBI taxonomy Id: 407821
Other names: S. mimosarum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
X975_00332	X975_01408	A0A087U5J0	A0A087UK68	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 13.	0.999
X975_00332	X975_05717	A0A087U5J0	A0A087UIR5	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 12.	0.999
X975_00332	X975_06809	A0A087U5J0	A0A087UPZ3	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 7; Belongs to the AAA ATPase family.	0.999
X975_00332	X975_07424	A0A087U5J0	A0A087T5U3	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.999
X975_00332	X975_10700	A0A087U5J0	A0A087TR95	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 7.	0.999
X975_00332	X975_11669	A0A087U5J0	A0A087UUW8	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family.	0.999
X975_00332	X975_17565	A0A087U5J0	A0A087TJS9	26S proteasome non-ATPase regulatory subunit 14.	Ubiquitin carboxyl-terminal hydrolase.	0.999
X975_00332	X975_22663	A0A087U5J0	A0A087U8E3	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
X975_00332	X975_24776	A0A087U5J0	A0A087UFL3	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 4.	0.999
X975_00332	X975_26864	A0A087U5J0	A0A087SVX7	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 1.	0.999
X975_01408	X975_00332	A0A087UK68	A0A087U5J0	26S proteasome non-ATPase regulatory subunit 13.	26S proteasome non-ATPase regulatory subunit 14.	0.999
X975_01408	X975_05717	A0A087UK68	A0A087UIR5	26S proteasome non-ATPase regulatory subunit 13.	26S proteasome non-ATPase regulatory subunit 12.	0.999
X975_01408	X975_06809	A0A087UK68	A0A087UPZ3	26S proteasome non-ATPase regulatory subunit 13.	26S protease regulatory subunit 7; Belongs to the AAA ATPase family.	0.999
X975_01408	X975_07424	A0A087UK68	A0A087T5U3	26S proteasome non-ATPase regulatory subunit 13.	26S protease regulatory subunit 8; Belongs to the AAA ATPase family.	0.998
X975_01408	X975_10700	A0A087UK68	A0A087TR95	26S proteasome non-ATPase regulatory subunit 13.	26S proteasome non-ATPase regulatory subunit 7.	0.999
X975_01408	X975_11669	A0A087UK68	A0A087UUW8	26S proteasome non-ATPase regulatory subunit 13.	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family.	0.999
X975_01408	X975_17565	A0A087UK68	A0A087TJS9	26S proteasome non-ATPase regulatory subunit 13.	Ubiquitin carboxyl-terminal hydrolase.	0.998
X975_01408	X975_22663	A0A087UK68	A0A087U8E3	26S proteasome non-ATPase regulatory subunit 13.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
X975_01408	X975_24776	A0A087UK68	A0A087UFL3	26S proteasome non-ATPase regulatory subunit 13.	26S proteasome non-ATPase regulatory subunit 4.	0.999
X975_01408	X975_26864	A0A087UK68	A0A087SVX7	26S proteasome non-ATPase regulatory subunit 13.	26S proteasome non-ATPase regulatory subunit 1.	0.997

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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