STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
X975_17822DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (546 aa)    
Predicted Functional Partners:
X975_11574
Fanconi anemia group M protein.
   
 0.993
X975_11576
Fanconi anemia group M protein.
   
 0.993
X975_23869
Fanconi anemia group M protein-like protein.
   
 0.993
X975_23870
Fanconi anemia group M protein.
   
 0.993
X975_10177
Tudor domain-containing protein 3.
    
 0.983
X975_19648
Werner syndrome ATP-dependent helicase.
  
 0.974
X975_19649
Werner syndrome ATP-dependent helicase.
  
 0.974
X975_19650
Werner syndrome ATP-dependent helicase.
  
 0.974
X975_20950
RecQ-mediated genome instability protein 1.
    
 0.964
X975_20951
DUF1767 domain-containing protein.
    
 0.964
Your Current Organism:
Stegodyphus mimosarum
NCBI taxonomy Id: 407821
Other names: S. mimosarum
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