X975_04163 protein (Stegodyphus mimosarum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

X975_04163

Uncharacterized protein. (745 aa)

Predicted Functional Partners:

X975_06232

0.729

X975_06233

0.729

X975_06235

0.729

X975_06236

0.729

X975_14793

0.729

X975_14794

0.729

X975_05502

0.729

X975_05504

0.729

X975_18228

0.614

X975_18229

0.614

Your Current Organism:

Stegodyphus mimosarum

NCBI taxonomy Id: 407821
Other names: S. mimosarum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
X975_04163	X975_05502	A0A087U3F8	A0A087UYB2	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_05504	A0A087U3F8	A0A087UYB4	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_06232	A0A087U3F8	A0A087UJ04	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_06233	A0A087U3F8	A0A087UJ05	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_06235	A0A087U3F8	A0A087UJ07	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_06236	A0A087U3F8	A0A087UJ08	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_14793	A0A087U3F8	A0A087UU94	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_14794	A0A087U3F8	A0A087UU95	Uncharacterized protein.	Techylectin-5A.	0.729
X975_04163	X975_18228	A0A087U3F8	A0A087TQ17	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type 11.	0.614
X975_04163	X975_18229	A0A087U3F8	A0A087TQ18	Uncharacterized protein.	Tyrosine-protein phosphatase corkscrew.	0.614
X975_05502	X975_04163	A0A087UYB2	A0A087U3F8	Techylectin-5A.	Uncharacterized protein.	0.729
X975_05502	X975_05504	A0A087UYB2	A0A087UYB4	Techylectin-5A.	Techylectin-5A.	0.648
X975_05502	X975_06232	A0A087UYB2	A0A087UJ04	Techylectin-5A.	Techylectin-5A.	0.655
X975_05502	X975_06233	A0A087UYB2	A0A087UJ05	Techylectin-5A.	Techylectin-5A.	0.656
X975_05502	X975_06235	A0A087UYB2	A0A087UJ07	Techylectin-5A.	Techylectin-5A.	0.657
X975_05502	X975_06236	A0A087UYB2	A0A087UJ08	Techylectin-5A.	Techylectin-5A.	0.653
X975_05502	X975_14793	A0A087UYB2	A0A087UU94	Techylectin-5A.	Techylectin-5A.	0.650
X975_05502	X975_14794	A0A087UYB2	A0A087UU95	Techylectin-5A.	Techylectin-5A.	0.650
X975_05502	X975_18228	A0A087UYB2	A0A087TQ17	Techylectin-5A.	Tyrosine-protein phosphatase non-receptor type 11.	0.501
X975_05502	X975_18229	A0A087UYB2	A0A087TQ18	Techylectin-5A.	Tyrosine-protein phosphatase corkscrew.	0.501

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.788

expected number of edges:

18

PPI enrichment p-value:

3.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

11 of 692

1.68

4.1

2.54e-15

GO:0007212

Dopamine receptor signaling pathway

4 of 29

2.62

3.4

4.04e-07

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

3 of 7

3.12

3.0

3.56e-06

GO:0031279

Regulation of cyclase activity

3 of 33

2.44

2.15

9.22e-05

GO:0007606

Sensory perception of chemical stimulus

3 of 38

2.38

2.06

0.00013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

3 of 13

2.85

2.41

3.97e-05

GO:0031683

G-protein beta/gamma-subunit complex binding

3 of 25

2.56

2.11

0.00012

GO:0030159

Signaling receptor complex adaptor activity

3 of 43

2.33

1.83

0.00036

GO:0044877

Protein-containing complex binding

6 of 1080

1.23

1.15

0.00036

GO:0001664

G protein-coupled receptor binding

3 of 161

1.75

1.04

0.0083

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

9 of 33

2.92

11.15

2.10e-22

GO:0005886

Plasma membrane

11 of 4843

0.84

0.91

6.11e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36820

Transducer, and G beta:gamma signalling through PLC beta

10 of 137

2.35

8.28

1.05e-19

CL:36832

GTPase complex, and Prostanoid receptor

7 of 33

2.81

7.87

6.44e-16

CL:36821

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

9 of 121

2.36

7.61

1.01e-17

CL:36824

Mixed, incl. GTPase complex, and Amine ligand-binding receptors

8 of 103

2.37

6.86

1.51e-15

CL:36833

GTPase complex, and GPCR, family 2, latrophilin

4 of 24

2.71

3.88

5.28e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

7 of 174

2.09

4.78

7.85e-12

map04020

Calcium signaling pathway

3 of 350

1.42

0.8

0.0182

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8964315

G beta:gamma signalling through BTK

7 of 12

3.25

9.49

2.83e-18

MAP-8964616

G beta:gamma signalling through CDC42

7 of 13

3.21

9.46

2.83e-18

MAP-500657

Presynaptic function of Kainate receptors

7 of 17

3.1

9.18

6.48e-18

MAP-418217

G beta:gamma signalling through PLC beta

7 of 17

3.1

9.18

6.48e-18

MAP-392170

ADP signalling through P2Y purinoceptor 12

7 of 17

3.1

9.18

6.48e-18

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

10 of 12472

0.39

0.32

0.0034

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 9

3.13

4.46

6.96e-09

GOCC:0005886

Plasma membrane

8 of 2309

1.02

1.08

1.37e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 261

1.67

1.54

0.00038

KW-0807

Transducer

4 of 315

1.59

1.48

0.00039

KW-0677

Repeat

4 of 866

1.15

0.73

0.0133

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

4 of 4

3.48

4.7

3.16e-09

IPR001632

G-protein, beta subunit

4 of 5

3.39

4.69

3.16e-09

IPR001770

G-protein, gamma subunit

3 of 8

3.06

2.74

1.04e-05

IPR036284

G-protein gamma-like domain superfamily

3 of 12

2.88

2.59

1.86e-05

IPR015898

G-protein gamma-like domain

3 of 12

2.88

2.59

1.86e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

2 of 11

2.74

1.39

0.0030

SM00320

WD40 repeats

4 of 283

1.63

1.32

0.0013

SM00275

G protein alpha subunit

2 of 19

2.51

1.24

0.0053

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