Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AKG44586.1Homeostasis protein; Belongs to the CutC family. (251 aa)    
Predicted Functional Partners:
AKG44587.1
Hypothetical protein.
 
     0.798
nadE
Nad+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
   
   0.756
AKG44585.1
Hypothetical protein.
       0.709
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
    0.574
AKG44584.1
Prevent-host-death family protein; Antitoxin component of a type II toxin-antitoxin (TA) system.
       0.520
AKG44834.1
Beta-n-acetylglucosaminidase.
 
     0.502
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.494
AKG45257.1
Glycosyl hydrolase family 20, catalytic domain protein.
 
     0.485
AKG41685.1
Phosphoenolpyruvate-dependent sugar phosphotransferase.
 
   
 0.435
AKG45619.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.421
Your Current Organism:
Streptomyces xiamenensis
NCBI taxonomy Id: 408015
Other names: CGMCC 4.3534, DSM 41903, JCM 16123, MCCC 1A01550, S. xiamenensis, Streptomyces sp. 1A01550, Streptomyces sp. USC025, Streptomyces sp. USC026, Streptomyces sp. VJPR-24, Streptomyces xiamenensis Xu et al. 2009
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.