Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mqnDMqnD, 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (306 aa)    
Predicted Functional Partners:
mqnC
Menaquinone biosynthetic enzyme; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
  
 0.995
mqnB
MqnB, futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
   
 0.991
mqnA
mqnA, Menaquinone via futalosine step 1; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
   
 0.955
mqnE
Radical SAM protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
 
   
 0.860
AKG44594.1
Lipoprotein.
       0.853
AKG44397.1
UbiA, prenyltransferase; Belongs to the UbiA prenyltransferase family.
 
   
 0.778
AKG44595.1
Integral membrane protein.
       0.761
AKG43607.1
UbiX, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase.
 
     0.728
AKG44396.1
UbiD, 4-hydroxy-3-polyprenylbenzoate decarboxylase; Belongs to the UbiD family.
  
     0.696
AKG44596.1
Hypothetical protein.
       0.678
Your Current Organism:
Streptomyces xiamenensis
NCBI taxonomy Id: 408015
Other names: CGMCC 4.3534, DSM 41903, JCM 16123, MCCC 1A01550, S. xiamenensis, Streptomyces sp. 1A01550, Streptomyces sp. USC025, Streptomyces sp. USC026, Streptomyces sp. VJPR-24, Streptomyces xiamenensis Xu et al. 2009
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