node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MPLB_1280006 | MPLB_2090004 | MPLB_1280006 | MPLB_2090004 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Putative bacteriophage-related transcriptional repressor. | 0.731 |
MPLB_1280006 | bamD | MPLB_1280006 | MPLB_1280007 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.835 |
MPLB_1280006 | lexA | MPLB_1280006 | MPLB_170062 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.899 |
MPLB_1280006 | ligA | MPLB_1280006 | MPLB_1280005 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.710 |
MPLB_1280006 | mfd | MPLB_1280006 | MPLB_1120005 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.670 |
MPLB_1280006 | pheT | MPLB_1280006 | MPLB_10003 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.685 |
MPLB_1280006 | recA | MPLB_1280006 | MPLB_1130024 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.917 |
MPLB_1280006 | ruvA | MPLB_1280006 | MPLB_640016 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.740 |
MPLB_1280006 | ruvB | MPLB_1280006 | MPLB_640015 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.660 |
MPLB_1280006 | xseA | MPLB_1280006 | MPLB_1380004 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.646 |
MPLB_2090004 | MPLB_1280006 | MPLB_2090004 | MPLB_1280006 | Putative bacteriophage-related transcriptional repressor. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.731 |
MPLB_2090004 | recA | MPLB_2090004 | MPLB_1130024 | Putative bacteriophage-related transcriptional repressor. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.995 |
bamD | MPLB_1280006 | MPLB_1280007 | MPLB_1280006 | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.835 |
bamD | ligA | MPLB_1280007 | MPLB_1280005 | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.563 |
bamD | pheT | MPLB_1280007 | MPLB_10003 | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.435 |
lexA | MPLB_1280006 | MPLB_170062 | MPLB_1280006 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.899 |
lexA | recA | MPLB_170062 | MPLB_1130024 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.996 |
lexA | ruvA | MPLB_170062 | MPLB_640016 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.450 |
ligA | MPLB_1280006 | MPLB_1280005 | MPLB_1280006 | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.710 |
ligA | bamD | MPLB_1280005 | MPLB_1280007 | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.563 |