node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MPLB_110030 | MPLB_1410003 | MPLB_110030 | MPLB_1410003 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Transmembrane efflux protein. | 0.693 |
MPLB_110030 | cdd | MPLB_110030 | MPLB_100079 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.921 |
MPLB_110030 | deoA | MPLB_110030 | MPLB_100081 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.911 |
MPLB_110030 | deoD | MPLB_110030 | MPLB_180024 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Purine-nucleoside phosphorylase. | 0.944 |
MPLB_110030 | prfA | MPLB_110030 | MPLB_1420003 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.493 |
MPLB_110030 | tdk | MPLB_110030 | MPLB_1550037 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.907 |
MPLB_110030 | thyA | MPLB_110030 | MPLB_1270106 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.885 |
MPLB_110030 | tmk | MPLB_110030 | MPLB_160009 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.890 |
MPLB_110030 | xapA | MPLB_110030 | MPLB_100080 | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.954 |
MPLB_1410003 | MPLB_110030 | MPLB_1410003 | MPLB_110030 | Transmembrane efflux protein. | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 0.693 |
MPLB_1410003 | dut | MPLB_1410003 | MPLB_780023 | Transmembrane efflux protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.755 |
MPLB_1410003 | tdk | MPLB_1410003 | MPLB_1550037 | Transmembrane efflux protein. | Thymidine kinase. | 0.759 |
MPLB_1410003 | thyA | MPLB_1410003 | MPLB_1270106 | Transmembrane efflux protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.774 |
MPLB_1410003 | tmk | MPLB_1410003 | MPLB_160009 | Transmembrane efflux protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.725 |
MPLB_1410003 | xapA | MPLB_1410003 | MPLB_100080 | Transmembrane efflux protein. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.410 |
cdd | MPLB_110030 | MPLB_100079 | MPLB_110030 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 5'-Nucleotidase domain protein; Belongs to the 5'-nucleotidase family. | 0.921 |
cdd | deoA | MPLB_100079 | MPLB_100081 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.997 |
cdd | deoD | MPLB_100079 | MPLB_180024 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Purine-nucleoside phosphorylase. | 0.937 |
cdd | tdk | MPLB_100079 | MPLB_1550037 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase. | 0.955 |
cdd | xapA | MPLB_100079 | MPLB_100080 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.994 |