node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MPLB_1270092 | gcvP | MPLB_1270092 | MPLB_1190011 | Phosphoserine phosphatase SerB. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.412 |
MPLB_1270092 | glyA-3 | MPLB_1270092 | MPLB_1710079 | Phosphoserine phosphatase SerB. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.899 |
MPLB_1270092 | sdaB | MPLB_1270092 | MPLB_180105 | Phosphoserine phosphatase SerB. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.906 |
MPLB_130045 | folD-3 | MPLB_130045 | MPLB_40004 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.452 |
MPLB_130045 | gcvH | MPLB_130045 | MPLB_1190010 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.968 |
MPLB_130045 | gcvP | MPLB_130045 | MPLB_1190011 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
MPLB_130045 | gcvT-2 | MPLB_130045 | MPLB_1190009 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.549 |
MPLB_130045 | glyA-3 | MPLB_130045 | MPLB_1710079 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.864 |
MPLB_130045 | sdaB | MPLB_130045 | MPLB_180105 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.593 |
MPLB_130045 | soxA | MPLB_130045 | MPLB_100096 | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha. | 0.887 |
folD-3 | MPLB_130045 | MPLB_40004 | MPLB_130045 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | 0.452 |
folD-3 | gcvP | MPLB_40004 | MPLB_1190011 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.759 |
folD-3 | gcvT-2 | MPLB_40004 | MPLB_1190009 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.951 |
folD-3 | glyA-3 | MPLB_40004 | MPLB_1710079 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
folD-3 | purH | MPLB_40004 | MPLB_660073 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.955 |
folD-3 | purN | MPLB_40004 | MPLB_1780004 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.940 |
folD-3 | soxA | MPLB_40004 | MPLB_100096 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Sarcosine oxidase subunit alpha. | 0.452 |
gcvH | MPLB_130045 | MPLB_1190010 | MPLB_130045 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Sarcosine oxidase, alpha subunit family; Belongs to the GcvT family. | 0.968 |
gcvH | gcvP | MPLB_1190010 | MPLB_1190011 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT-2 | MPLB_1190010 | MPLB_1190009 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.999 |