| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MPLA_1550039 | MPLA_1800080 | MPLA_1550039 | MPLA_1800080 | Riboflavin synthase alpha chain. | HAD-superfamily hydrolase, subfamily IIB. | 0.569 |
| MPLA_1550039 | folE | MPLA_1550039 | MPLA_290029 | Riboflavin synthase alpha chain. | GTP cyclohydrolase 1. | 0.710 |
| MPLA_1550039 | folP | MPLA_1550039 | MPLA_970015 | Riboflavin synthase alpha chain. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.670 |
| MPLA_1550039 | nrdR | MPLA_1550039 | MPLA_1550037 | Riboflavin synthase alpha chain. | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.775 |
| MPLA_1550039 | ribB | MPLA_1550039 | MPLA_1800028 | Riboflavin synthase alpha chain. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| MPLA_1550039 | ribD | MPLA_1550039 | MPLA_1550038 | Riboflavin synthase alpha chain. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| MPLA_1550039 | ribE | MPLA_1550039 | MPLA_1550041 | Riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| MPLA_1550039 | ribF | MPLA_1550039 | MPLA_730019 | Riboflavin synthase alpha chain. | Riboflavin biosynthesis protein; Belongs to the ribF family. | 0.925 |
| MPLA_1550039 | ribH | MPLA_1550039 | MPLA_1390165 | Riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.997 |
| MPLA_1550039 | rutF | MPLA_1550039 | MPLA_30129 | Riboflavin synthase alpha chain. | Flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway. | 0.597 |
| MPLA_1800080 | MPLA_1550039 | MPLA_1800080 | MPLA_1550039 | HAD-superfamily hydrolase, subfamily IIB. | Riboflavin synthase alpha chain. | 0.569 |
| MPLA_1800080 | ribB | MPLA_1800080 | MPLA_1800028 | HAD-superfamily hydrolase, subfamily IIB. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.738 |
| MPLA_1800080 | ribD | MPLA_1800080 | MPLA_1550038 | HAD-superfamily hydrolase, subfamily IIB. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.871 |
| MPLA_1800080 | ribE | MPLA_1800080 | MPLA_1550041 | HAD-superfamily hydrolase, subfamily IIB. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.636 |
| MPLA_1800080 | ribF | MPLA_1800080 | MPLA_730019 | HAD-superfamily hydrolase, subfamily IIB. | Riboflavin biosynthesis protein; Belongs to the ribF family. | 0.686 |
| MPLA_1800080 | ribH | MPLA_1800080 | MPLA_1390165 | HAD-superfamily hydrolase, subfamily IIB. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.636 |
| MPLA_1800080 | rutF | MPLA_1800080 | MPLA_30129 | HAD-superfamily hydrolase, subfamily IIB. | Flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway. | 0.556 |
| folE | MPLA_1550039 | MPLA_290029 | MPLA_1550039 | GTP cyclohydrolase 1. | Riboflavin synthase alpha chain. | 0.710 |
| folE | folP | MPLA_290029 | MPLA_970015 | GTP cyclohydrolase 1. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.994 |
| folE | ribB | MPLA_290029 | MPLA_1800028 | GTP cyclohydrolase 1. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.927 |