topA protein (Mesorhizobium sp. ORS3359) - STRING interaction network

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topA

DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (855 aa)

Predicted Functional Partners:

recQ

0.974

recA

0.953

rpoC

0.946

MPLA_250062

0.945

MPLA_2130147

0.932

MPLA_1280035

0.922

MPLA_1620051

0.922

MPLA_320027

0.922

MPLA_70029

0.922

dnaG

0.916

Your Current Organism:

Mesorhizobium sp. ORS3359

NCBI taxonomy Id: 408184
Other names: M. sp. ORS 3359, Mesorhizobium sp. ORS 3359

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MPLA_1280035	MPLA_2130147	MPLA_1280035	MPLA_2130147	DNA helicase.	AAA_13 domain-containing protein.	0.724
MPLA_1280035	MPLA_250062	MPLA_1280035	MPLA_250062	DNA helicase.	DNA helicase.	0.657
MPLA_1280035	dnaG	MPLA_1280035	MPLA_80032	DNA helicase.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.798
MPLA_1280035	recA	MPLA_1280035	MPLA_30094	DNA helicase.	Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.788
MPLA_1280035	recQ	MPLA_1280035	MPLA_570029	DNA helicase.	ATP-dependent DNA helicase.	0.923
MPLA_1280035	rpoC	MPLA_1280035	MPLA_1820012	DNA helicase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.490
MPLA_1280035	topA	MPLA_1280035	MPLA_270008	DNA helicase.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.922
MPLA_1620051	MPLA_2130147	MPLA_1620051	MPLA_2130147	DNA helicase.	AAA_13 domain-containing protein.	0.677
MPLA_1620051	MPLA_250062	MPLA_1620051	MPLA_250062	DNA helicase.	DNA helicase.	0.721
MPLA_1620051	dnaG	MPLA_1620051	MPLA_80032	DNA helicase.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.802
MPLA_1620051	recA	MPLA_1620051	MPLA_30094	DNA helicase.	Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.838
MPLA_1620051	recQ	MPLA_1620051	MPLA_570029	DNA helicase.	ATP-dependent DNA helicase.	0.923
MPLA_1620051	rpoC	MPLA_1620051	MPLA_1820012	DNA helicase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.584
MPLA_1620051	topA	MPLA_1620051	MPLA_270008	DNA helicase.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.922
MPLA_2130147	MPLA_1280035	MPLA_2130147	MPLA_1280035	AAA_13 domain-containing protein.	DNA helicase.	0.724
MPLA_2130147	MPLA_1620051	MPLA_2130147	MPLA_1620051	AAA_13 domain-containing protein.	DNA helicase.	0.677
MPLA_2130147	MPLA_250062	MPLA_2130147	MPLA_250062	AAA_13 domain-containing protein.	DNA helicase.	0.677
MPLA_2130147	MPLA_320027	MPLA_2130147	MPLA_320027	AAA_13 domain-containing protein.	Putative NERD domain protein.	0.677
MPLA_2130147	MPLA_70029	MPLA_2130147	MPLA_70029	AAA_13 domain-containing protein.	LssY_C domain-containing protein.	0.677
MPLA_2130147	recA	MPLA_2130147	MPLA_30094	AAA_13 domain-containing protein.	Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.920

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