STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HPRGlyoxylate/hydroxypyruvate reductase A HPR2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)    
Predicted Functional Partners:
MPLA_340142
Transcriptional regulator.
 
    0.863
maeB
Putative fused malic enzyme oxidoreductase phosphotransacetylase.
   
 0.815
maeB-2
Putative fused malic enzyme oxidoreductase phosphotransacetylase.
   
 0.815
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
 
 0.806
MPLA_670004
Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
 
0.794
pykA
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.785
folC
Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.
    
  0.753
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
  0.753
gcvT
Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex.
   
 
  0.744
sgaA
Serine--glyoxylate aminotransferase.
 
 
 0.737
Your Current Organism:
Mesorhizobium sp. ORS3359
NCBI taxonomy Id: 408184
Other names: M. sp. ORS 3359, Mesorhizobium sp. ORS 3359
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