Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MPLA_440008ACT_3 domain-containing protein. (135 aa)    
Predicted Functional Partners:
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
      0.616
MPLA_440009
Uncharacterized protein.
       0.521
folC
Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.
     
  0.400
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
  0.400
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
  0.400
MPLA_320156
Homocysteine S-methyltransferase.
     
  0.400
MPLA_320174
5-methyltetrahydrofolate S-homocysteine methyltransferase.
     
  0.400
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
     
  0.400
Your Current Organism:
Mesorhizobium sp. ORS3359
NCBI taxonomy Id: 408184
Other names: M. sp. ORS 3359, Mesorhizobium sp. ORS 3359
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