node1 | node2 | node1 annotation | node2 annotation | score |
ENSPMGP00000005117 | ENSPMGP00000005595 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | 0.754 |
ENSPMGP00000005117 | ENSPMGP00000012406 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Potassium channel tetramerization domain containing 2. | 0.754 |
ENSPMGP00000005117 | ENSPMGP00000014568 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.754 |
ENSPMGP00000005117 | ENSPMGP00000021037 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.775 |
ENSPMGP00000005117 | ENSPMGP00000025531 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Small ubiquitin-related modifier. | 0.765 |
ENSPMGP00000005117 | ENSPMGP00000026544 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | RecQ helicase-like 4. | 0.726 |
ENSPMGP00000005117 | ENSPMGP00000028766 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Tyrosyl-DNA phosphodiesterase 1. | 0.497 |
ENSPMGP00000005117 | ENSPMGP00000029058 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.561 |
ENSPMGP00000005595 | ENSPMGP00000005117 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.754 |
ENSPMGP00000005595 | ENSPMGP00000009996 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | TOP4c domain-containing protein. | 0.754 |
ENSPMGP00000005595 | ENSPMGP00000010002 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | HATPase_c domain-containing protein. | 0.754 |
ENSPMGP00000005595 | ENSPMGP00000021037 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.773 |
ENSPMGP00000005595 | ENSPMGP00000025531 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier. | 0.997 |
ENSPMGP00000005595 | ENSPMGP00000026544 | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | RecQ helicase-like 4. | 0.786 |
ENSPMGP00000009996 | ENSPMGP00000005595 | TOP4c domain-containing protein. | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. | 0.754 |
ENSPMGP00000009996 | ENSPMGP00000010002 | TOP4c domain-containing protein. | HATPase_c domain-containing protein. | 0.900 |
ENSPMGP00000009996 | ENSPMGP00000012406 | TOP4c domain-containing protein. | Potassium channel tetramerization domain containing 2. | 0.754 |
ENSPMGP00000009996 | ENSPMGP00000014568 | TOP4c domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.754 |
ENSPMGP00000009996 | ENSPMGP00000021037 | TOP4c domain-containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.775 |
ENSPMGP00000009996 | ENSPMGP00000025531 | TOP4c domain-containing protein. | Small ubiquitin-related modifier. | 0.765 |