B9Z65_6529 protein (Elsinoe australis) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Score

B9Z65_6529

MI domain-containing protein. (860 aa)

Predicted Functional Partners:

B9Z65_5569

0.979

B9Z65_997

0.977

B9Z65_1823

0.974

B9Z65_6385

0.972

B9Z65_8322

0.971

NAT10

0.966

B9Z65_2508

0.965

B9Z65_5236

0.965

B9Z65_4675

0.964

B9Z65_2370

0.960

Your Current Organism:

Elsinoe australis

NCBI taxonomy Id: 40998
Other names: E. australis, Sphaceloma australis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9Z65_1823	B9Z65_2370	A0A2P7YL09	A0A2P7ZAJ0	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	rRNA bioproteinsis protein RRP36.	0.702
B9Z65_1823	B9Z65_2508	A0A2P7YL09	A0A2P7ZAX2	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	Sas10 domain-containing protein.	0.748
B9Z65_1823	B9Z65_4675	A0A2P7YL09	A0A2P8A5R7	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	CBF domain-containing protein.	0.698
B9Z65_1823	B9Z65_5236	A0A2P7YL09	A0A2P7ZDI4	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	Pre-rRNA-processing protein esf1.	0.579
B9Z65_1823	B9Z65_5569	A0A2P7YL09	A0A2P7ZJK3	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	RNA helicase.	0.674
B9Z65_1823	B9Z65_6385	A0A2P7YL09	A0A2P8A8H0	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.971
B9Z65_1823	B9Z65_6529	A0A2P7YL09	A0A2P8A8W8	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	MI domain-containing protein.	0.974
B9Z65_1823	B9Z65_8322	A0A2P7YL09	A0A2P7YDF5	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.767
B9Z65_1823	B9Z65_997	A0A2P7YL09	A0A2P8AK77	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	WD_REPEATS_REGION domain-containing protein.	0.517
B9Z65_1823	NAT10	A0A2P7YL09	A0A2P8AK14	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.571
B9Z65_2370	B9Z65_1823	A0A2P7ZAJ0	A0A2P7YL09	rRNA bioproteinsis protein RRP36.	ATP-dependent RNA helicase fal1; Belongs to the DEAD box helicase family.	0.702
B9Z65_2370	B9Z65_2508	A0A2P7ZAJ0	A0A2P7ZAX2	rRNA bioproteinsis protein RRP36.	Sas10 domain-containing protein.	0.990
B9Z65_2370	B9Z65_4675	A0A2P7ZAJ0	A0A2P8A5R7	rRNA bioproteinsis protein RRP36.	CBF domain-containing protein.	0.841
B9Z65_2370	B9Z65_5236	A0A2P7ZAJ0	A0A2P7ZDI4	rRNA bioproteinsis protein RRP36.	Pre-rRNA-processing protein esf1.	0.437
B9Z65_2370	B9Z65_5569	A0A2P7ZAJ0	A0A2P7ZJK3	rRNA bioproteinsis protein RRP36.	RNA helicase.	0.972
B9Z65_2370	B9Z65_6385	A0A2P7ZAJ0	A0A2P8A8H0	rRNA bioproteinsis protein RRP36.	Uncharacterized protein.	0.745
B9Z65_2370	B9Z65_6529	A0A2P7ZAJ0	A0A2P8A8W8	rRNA bioproteinsis protein RRP36.	MI domain-containing protein.	0.960
B9Z65_2370	B9Z65_8322	A0A2P7ZAJ0	A0A2P7YDF5	rRNA bioproteinsis protein RRP36.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.990
B9Z65_2370	B9Z65_997	A0A2P7ZAJ0	A0A2P8AK77	rRNA bioproteinsis protein RRP36.	WD_REPEATS_REGION domain-containing protein.	0.695
B9Z65_2370	NAT10	A0A2P7ZAJ0	A0A2P8AK14	rRNA bioproteinsis protein RRP36.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.472

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.848

expected number of edges:

11

PPI enrichment p-value:

5.84e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

3 of 3

3.26

2.54

2.61e-05

GO:0006225

UDP biosynthetic process

3 of 4

3.14

2.53

2.61e-05

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

3 of 6

2.96

2.52

2.61e-05

GO:0009156

Ribonucleoside monophosphate biosynthetic process

4 of 36

2.31

2.38

2.61e-05

GO:0016126

Sterol biosynthetic process

3 of 36

2.18

1.77

0.00039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004128

cytochrome-b5 reductase activity, acting on NAD(P)H

5 of 5

3.26

5.97

1.24e-11

GO:0071949

FAD binding

4 of 41

2.25

2.69

5.25e-06

GO:0004151

Dihydroorotase activity

2 of 2

3.26

1.75

0.00069

GO:0016491

Oxidoreductase activity

7 of 847

1.18

1.26

4.01e-05

GO:0016884

Carbon-nitrogen ligase activity, with glutamine as amido-N-donor

2 of 10

2.56

1.22

0.0059

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34822617

(2021) Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.

5 of 5

3.26

5.28

2.39e-10

PMID:32039242

(2019) Methemoglobin Modulation as an Intravascular Contrast Agent for Magnetic Resonance Imaging: Proof of Concept.

5 of 5

3.26

5.28

2.39e-10

PMID:12030383

(2002) Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in swiss mice and beagle dogs erythrocytes.

5 of 5

3.26

5.28

2.39e-10

PMID:35202847

(2022) Oral Methylene Blue Treatment in A Dog with Cytochrome B5 Reductase Deficiency And 78, XX Testicular Disorder of Sex Development.

5 of 6

3.18

5.26

2.39e-10

PMID:22135611

(2011) Body weight reducing effect of oral boric acid intake.

5 of 6

3.18

5.26

2.39e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6070

Mixed, incl. cytochrome-b5 reductase activity, acting on NAD(P)H, and Amidohydrolase family

7 of 21

2.79

7.36

6.43e-15

CL:6072

Mixed, incl. L-ascorbic acid transmembrane transport, and Pyrimidine biosynthesis

4 of 12

2.79

3.71

1.30e-07

CL:6100

Nitric-oxide synthase complex, and cytochrome-b5 reductase activity, acting on NAD(P)H

3 of 6

2.96

2.71

1.13e-05

CL:6075

Mixed, incl. Pyrimidine biosynthesis, and Pyrimidine catabolism

3 of 7

2.9

2.67

1.30e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00520

Amino sugar and nucleotide sugar metabolism

5 of 42

2.34

4.02

8.29e-09

cfa00983

Drug metabolism - other enzymes

2 of 41

1.95

0.74

0.0399

cfa00240

Pyrimidine metabolism

2 of 42

1.94

0.74

0.0399

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-1237044

Erythrocytes take up carbon dioxide and release oxygen

4 of 10

2.87

3.85

7.59e-08

CFA-8956320

Nucleotide biosynthesis

4 of 12

2.79

3.83

7.59e-08

CFA-500753

Pyrimidine biosynthesis

3 of 3

3.26

3.32

9.59e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0285

Flavoprotein

6 of 68

2.21

4.42

3.68e-10

KW-0274

FAD

5 of 61

2.18

3.61

2.98e-08

KW-0520

NAD

4 of 91

1.91

2.25

1.52e-05

KW-0560

Oxidoreductase

5 of 234

1.59

1.93

1.33e-05

KW-0315

Glutamine amidotransferase

2 of 6

2.79

1.76

0.00062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

6 of 11

3.0

6.89

1.38e-13

PF00970

Oxidoreductase FAD-binding domain

5 of 5

3.26

6.19

4.75e-12

PF00117

Glutamine amidotransferase class-I

2 of 3

3.09

1.48

0.0021

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