node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | hisE | ERS852525_02431 | ERS852525_00288 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.838 |
apt | hisF_1 | ERS852525_02431 | ERS852525_02307 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.906 |
apt | hisH1 | ERS852525_02431 | ERS852525_02306 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.899 |
apt | purH | ERS852525_02431 | ERS852525_01332 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional purine biosynthesis protein PurH. | 0.964 |
hisB | hisC | ERS852525_00289 | ERS852525_02481 | Histidine biosynthesis bifunctional protein hisB. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | ERS852525_00289 | ERS852525_00290 | Histidine biosynthesis bifunctional protein hisB. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | ERS852525_00289 | ERS852525_00288 | Histidine biosynthesis bifunctional protein hisB. | Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB | hisF_1 | ERS852525_00289 | ERS852525_02307 | Histidine biosynthesis bifunctional protein hisB. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisF_2 | ERS852525_00289 | ERS852525_02649 | Histidine biosynthesis bifunctional protein hisB. | Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. | 0.960 |
hisB | hisG | ERS852525_00289 | ERS852525_00291 | Histidine biosynthesis bifunctional protein hisB. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
hisB | hisH1 | ERS852525_00289 | ERS852525_02306 | Histidine biosynthesis bifunctional protein hisB. | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisZ | ERS852525_00289 | ERS852525_00292 | Histidine biosynthesis bifunctional protein hisB. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.996 |
hisC | hisB | ERS852525_02481 | ERS852525_00289 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidine biosynthesis bifunctional protein hisB. | 0.998 |
hisC | hisD | ERS852525_02481 | ERS852525_00290 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisC | hisE | ERS852525_02481 | ERS852525_00288 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.993 |
hisC | hisF_1 | ERS852525_02481 | ERS852525_02307 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.914 |
hisC | hisF_2 | ERS852525_02481 | ERS852525_02649 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazole glycerol phosphate synthase subunit HisF; Belongs to the HisA/HisF family. | 0.803 |
hisC | hisG | ERS852525_02481 | ERS852525_00291 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.892 |
hisC | hisH1 | ERS852525_02481 | ERS852525_02306 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.899 |
hisC | hisZ | ERS852525_02481 | ERS852525_00292 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.709 |