node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0160 | Mlab_1348 | Mlab_0160 | Mlab_1348 | PFAM: helix-turn-helix domain protein. | PFAM: PUA domain containing protein. | 0.434 |
Mlab_0160 | Mlab_1628 | Mlab_0160 | Mlab_1628 | PFAM: helix-turn-helix domain protein. | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | 0.514 |
Mlab_0160 | carS | Mlab_0160 | Mlab_0318 | PFAM: helix-turn-helix domain protein. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.643 |
Mlab_0160 | dnaG | Mlab_0160 | Mlab_0361 | PFAM: helix-turn-helix domain protein. | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.421 |
Mlab_0160 | priS | Mlab_0160 | Mlab_1303 | PFAM: helix-turn-helix domain protein. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.651 |
Mlab_0319 | carS | Mlab_0319 | Mlab_0318 | PFAM: Radical SAM domain protein. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.720 |
Mlab_0319 | pyrE | Mlab_0319 | Mlab_0317 | PFAM: Radical SAM domain protein. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.626 |
Mlab_0431 | Mlab_0795 | Mlab_0431 | Mlab_0795 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.977 |
Mlab_0431 | carS | Mlab_0431 | Mlab_0318 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.910 |
Mlab_0795 | Mlab_0431 | Mlab_0795 | Mlab_0431 | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. | 0.977 |
Mlab_0795 | carS | Mlab_0795 | Mlab_0318 | Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.966 |
Mlab_1348 | Mlab_0160 | Mlab_1348 | Mlab_0160 | PFAM: PUA domain containing protein. | PFAM: helix-turn-helix domain protein. | 0.434 |
Mlab_1348 | Mlab_1628 | Mlab_1348 | Mlab_1628 | PFAM: PUA domain containing protein. | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | 0.551 |
Mlab_1348 | carS | Mlab_1348 | Mlab_0318 | PFAM: PUA domain containing protein. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.673 |
Mlab_1348 | dnaG | Mlab_1348 | Mlab_0361 | PFAM: PUA domain containing protein. | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.473 |
Mlab_1348 | priS | Mlab_1348 | Mlab_1303 | PFAM: PUA domain containing protein. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.611 |
Mlab_1628 | Mlab_0160 | Mlab_1628 | Mlab_0160 | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | PFAM: helix-turn-helix domain protein. | 0.514 |
Mlab_1628 | Mlab_1348 | Mlab_1628 | Mlab_1348 | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | PFAM: PUA domain containing protein. | 0.551 |
Mlab_1628 | carS | Mlab_1628 | Mlab_0318 | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.643 |
Mlab_1628 | dnaG | Mlab_1628 | Mlab_0361 | Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein. | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.429 |