STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlab_0435PFAM: Protein of unknown function DUF460. (767 aa)    
Predicted Functional Partners:
Mlab_0434
PFAM: protein of unknown function RIO1.
 
     0.910
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.849
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
   
 0.669
Mlab_1569
DNA-directed RNA polymerase, subunit F; PFAM: RNA polymerase Rpb4.
  
     0.625
Mlab_1173
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein.
  
     0.604
nusA-2
NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.
 
     0.597
Mlab_0662
PFAM: Oligosaccharyl transferase, STT3 subunit.
  
     0.593
Mlab_0400
ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication.
  
     0.586
Mlab_0117
PFAM: Radical SAM domain protein.
 
     0.563
Mlab_0635
PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type.
 
     0.547
Your Current Organism:
Methanocorpusculum labreanum
NCBI taxonomy Id: 410358
Other names: M. labreanum Z, Methanocorpusculum labreanum Z, Methanocorpusculum labreanum str. Z, Methanocorpusculum labreanum strain Z
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.