STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mlab_0524Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (315 aa)    
Predicted Functional Partners:
Mlab_0526
TIGRFAM: porphobilinogen deaminase; uroporphyrin-III C-methyltransferase; PFAM: Porphobilinogen deaminase; Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
 
 
 0.999
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
 
 0.998
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.960
Mlab_0522
TIGRFAM: siroheme synthase.
     
 0.850
cbiA
Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
  
  
 0.845
Mlab_0518
PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein.
     
 0.832
Mlab_0519
UDP-N-acetylmuramyl pentapeptide synthase-like protein.
     
 0.800
Mlab_0520
Nitrogenase molybdenum-iron protein alpha and beta chains-like protein.
       0.794
Mlab_0073
Uroporphyrinogen-III synthase-like protein.
  
 
 0.728
Mlab_0359
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.728
Your Current Organism:
Methanocorpusculum labreanum
NCBI taxonomy Id: 410358
Other names: M. labreanum Z, Methanocorpusculum labreanum Z, Methanocorpusculum labreanum str. Z, Methanocorpusculum labreanum strain Z
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.