node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0705 | Mlab_1672 | Mlab_0705 | Mlab_1672 | PFAM: protein of unknown function DUF105; cysteine-rich small domain. | PFAM: protein of unknown function DUF105; cysteine-rich small domain. | 0.905 |
Mlab_0705 | cobD | Mlab_0705 | Mlab_0061 | PFAM: protein of unknown function DUF105; cysteine-rich small domain. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.944 |
Mlab_0705 | cobQ | Mlab_0705 | Mlab_1099 | PFAM: protein of unknown function DUF105; cysteine-rich small domain. | Cobyrinic acid a,c-diamide synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.923 |
Mlab_0705 | cobS | Mlab_0705 | Mlab_1443 | PFAM: protein of unknown function DUF105; cysteine-rich small domain. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.450 |
Mlab_0745 | Mlab_1078 | Mlab_0745 | Mlab_1078 | PFAM: aminotransferase, class I and II. | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.639 |
Mlab_0745 | cbiA-2 | Mlab_0745 | Mlab_1072 | PFAM: aminotransferase, class I and II. | Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.926 |
Mlab_0745 | cobD | Mlab_0745 | Mlab_0061 | PFAM: aminotransferase, class I and II. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.964 |
Mlab_0745 | cobQ | Mlab_0745 | Mlab_1099 | PFAM: aminotransferase, class I and II. | Cobyrinic acid a,c-diamide synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.958 |
Mlab_0745 | cobS | Mlab_0745 | Mlab_1443 | PFAM: aminotransferase, class I and II. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.583 |
Mlab_1077 | Mlab_1078 | Mlab_1077 | Mlab_1078 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.999 |
Mlab_1077 | Mlab_1080 | Mlab_1077 | Mlab_1080 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | 0.995 |
Mlab_1077 | Mlab_1081 | Mlab_1077 | Mlab_1081 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: Precorrin-8X methylmutase CbiC/CobH. | 0.997 |
Mlab_1077 | cbiA-2 | Mlab_1077 | Mlab_1072 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.637 |
Mlab_1077 | cobD | Mlab_1077 | Mlab_0061 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.532 |
Mlab_1077 | cobQ | Mlab_1077 | Mlab_1099 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyrinic acid a,c-diamide synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.957 |
Mlab_1077 | cobS | Mlab_1077 | Mlab_1443 | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.756 |
Mlab_1078 | Mlab_0745 | Mlab_1078 | Mlab_0745 | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: aminotransferase, class I and II. | 0.639 |
Mlab_1078 | Mlab_1077 | Mlab_1078 | Mlab_1077 | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalt-factor II C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.999 |
Mlab_1078 | Mlab_1080 | Mlab_1078 | Mlab_1080 | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. | 0.999 |
Mlab_1078 | Mlab_1081 | Mlab_1078 | Mlab_1081 | Precorrin-4 C(11)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: Precorrin-8X methylmutase CbiC/CobH. | 0.996 |