node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0616 | Mlab_1661 | Mlab_0616 | Mlab_1661 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.852 |
Mlab_0616 | fen | Mlab_0616 | Mlab_0356 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.970 |
Mlab_0616 | lig | Mlab_0616 | Mlab_0620 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.880 |
Mlab_0616 | mutL | Mlab_0616 | Mlab_1168 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.520 |
Mlab_0616 | mutS | Mlab_0616 | Mlab_1169 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.839 |
Mlab_0616 | pcn | Mlab_0616 | Mlab_1253 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.995 |
Mlab_0616 | polB | Mlab_0616 | Mlab_0004 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.999 |
Mlab_0616 | priL | Mlab_0616 | Mlab_1252 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.993 |
Mlab_0616 | priS | Mlab_0616 | Mlab_1303 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.992 |
Mlab_0616 | rpl40e | Mlab_0616 | Mlab_0651 | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | PFAM: Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.788 |
Mlab_1661 | Mlab_0616 | Mlab_1661 | Mlab_0616 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | 0.852 |
Mlab_1661 | fen | Mlab_1661 | Mlab_0356 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.662 |
Mlab_1661 | lig | Mlab_1661 | Mlab_0620 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.636 |
Mlab_1661 | mutL | Mlab_1661 | Mlab_1168 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.491 |
Mlab_1661 | mutS | Mlab_1661 | Mlab_1169 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.881 |
Mlab_1661 | pcn | Mlab_1661 | Mlab_1253 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.956 |
Mlab_1661 | polB | Mlab_1661 | Mlab_0004 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.639 |
Mlab_1661 | priL | Mlab_1661 | Mlab_1252 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.890 |
Mlab_1661 | priS | Mlab_1661 | Mlab_1303 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.883 |
Mlab_1661 | rpl40e | Mlab_1661 | Mlab_0651 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.561 |