node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0482 | Mlab_1109 | Mlab_0482 | Mlab_1109 | PFAM: amino acid-binding ACT domain protein. | Metal-binding transcription factor-like protein. | 0.477 |
Mlab_0482 | cofC | Mlab_0482 | Mlab_1358 | PFAM: amino acid-binding ACT domain protein. | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.665 |
Mlab_0482 | mer | Mlab_0482 | Mlab_0076 | PFAM: amino acid-binding ACT domain protein. | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. | 0.442 |
Mlab_1109 | Mlab_0482 | Mlab_1109 | Mlab_0482 | Metal-binding transcription factor-like protein. | PFAM: amino acid-binding ACT domain protein. | 0.477 |
Mlab_1109 | cofC | Mlab_1109 | Mlab_1358 | Metal-binding transcription factor-like protein. | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.631 |
Mlab_1109 | mer | Mlab_1109 | Mlab_0076 | Metal-binding transcription factor-like protein. | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. | 0.482 |
Mlab_1332 | Mlab_1335 | Mlab_1332 | Mlab_1335 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | 0.967 |
Mlab_1332 | cofC | Mlab_1332 | Mlab_1358 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.738 |
Mlab_1332 | cofD | Mlab_1332 | Mlab_0152 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.983 |
Mlab_1332 | cofG | Mlab_1332 | Mlab_1590 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.739 |
Mlab_1332 | mer | Mlab_1332 | Mlab_0076 | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. | 0.767 |
Mlab_1335 | Mlab_1332 | Mlab_1335 | Mlab_1332 | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Coenzyme F420-0 gamma-glutamyl ligase; TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | 0.967 |
Mlab_1335 | cofC | Mlab_1335 | Mlab_1358 | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.697 |
Mlab_1335 | cofD | Mlab_1335 | Mlab_0152 | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.983 |
Mlab_1335 | cofG | Mlab_1335 | Mlab_1590 | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. | 0.721 |
Mlab_1335 | mer | Mlab_1335 | Mlab_0076 | TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129. | Methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. | 0.765 |
Mlab_1357 | Mlab_1359 | Mlab_1357 | Mlab_1359 | TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS. | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein. | 0.643 |
Mlab_1357 | cofC | Mlab_1357 | Mlab_1358 | TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS. | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.628 |
Mlab_1357 | glyA | Mlab_1357 | Mlab_1356 | TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.846 |
Mlab_1359 | Mlab_1357 | Mlab_1359 | Mlab_1357 | PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein. | TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS. | 0.643 |