node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mlab_0404 | Mlab_0844 | Mlab_0404 | Mlab_0844 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.527 |
Mlab_0404 | Mlab_1256 | Mlab_0404 | Mlab_1256 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.531 |
Mlab_0404 | aroA-2 | Mlab_0404 | Mlab_1650 | PFAM: AMP-dependent synthetase and ligase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.901 |
Mlab_0598 | Mlab_1648 | Mlab_0598 | Mlab_1648 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | PFAM: Chorismate mutase; Prephenate dehydrogenase. | 0.934 |
Mlab_0598 | aroA-2 | Mlab_0598 | Mlab_1650 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.726 |
Mlab_0598 | aroB | Mlab_0598 | Mlab_1653 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | 3-dehydroquinate synthase II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. | 0.766 |
Mlab_0598 | aroC | Mlab_0598 | Mlab_1649 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.681 |
Mlab_0598 | aroE | Mlab_0598 | Mlab_1652 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.686 |
Mlab_0844 | Mlab_0404 | Mlab_0844 | Mlab_0404 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.527 |
Mlab_0844 | Mlab_1256 | Mlab_0844 | Mlab_1256 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.901 |
Mlab_0844 | aroA-2 | Mlab_0844 | Mlab_1650 | PFAM: AMP-dependent synthetase and ligase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.797 |
Mlab_1256 | Mlab_0404 | Mlab_1256 | Mlab_0404 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.531 |
Mlab_1256 | Mlab_0844 | Mlab_1256 | Mlab_0844 | PFAM: AMP-dependent synthetase and ligase. | PFAM: AMP-dependent synthetase and ligase. | 0.901 |
Mlab_1256 | aroA-2 | Mlab_1256 | Mlab_1650 | PFAM: AMP-dependent synthetase and ligase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.849 |
Mlab_1648 | Mlab_0598 | Mlab_1648 | Mlab_0598 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. | 0.934 |
Mlab_1648 | aroA-2 | Mlab_1648 | Mlab_1650 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.872 |
Mlab_1648 | aroA-3 | Mlab_1648 | Mlab_1654 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.823 |
Mlab_1648 | aroB | Mlab_1648 | Mlab_1653 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | 3-dehydroquinate synthase II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. | 0.842 |
Mlab_1648 | aroC | Mlab_1648 | Mlab_1649 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.985 |
Mlab_1648 | aroE | Mlab_1648 | Mlab_1652 | PFAM: Chorismate mutase; Prephenate dehydrogenase. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.873 |