node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcal_0089 | Pcal_0133 | Pcal_0089 | Pcal_0133 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | 0.924 |
Pcal_0089 | Pcal_0136 | Pcal_0089 | Pcal_0136 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | PFAM: histidinol dehydrogenase; KEGG: pai:PAE0988 histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | 0.979 |
Pcal_0089 | Pcal_0140 | Pcal_0089 | Pcal_0140 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis; KEGG: pai:PAE0991 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.904 |
Pcal_0089 | hisB | Pcal_0089 | Pcal_0139 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pai:PAE0990 imidazoleglycerol-phosphate dehydratase. | 0.998 |
Pcal_0089 | hisE | Pcal_0089 | Pcal_0135 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pai:PAE0986 phosphoribosyl-ATP pyrophosphohydrolase. | 0.874 |
Pcal_0089 | hisF | Pcal_0089 | Pcal_0137 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.926 |
Pcal_0089 | hisG | Pcal_0089 | Pcal_0134 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.933 |
Pcal_0089 | hisH | Pcal_0089 | Pcal_0130 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.935 |
Pcal_0089 | hisI | Pcal_0089 | Pcal_0131 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.914 |
Pcal_0133 | Pcal_0089 | Pcal_0133 | Pcal_0089 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | 0.924 |
Pcal_0133 | Pcal_0136 | Pcal_0133 | Pcal_0136 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | PFAM: histidinol dehydrogenase; KEGG: pai:PAE0988 histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | 0.991 |
Pcal_0133 | Pcal_0140 | Pcal_0133 | Pcal_0140 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis; KEGG: pai:PAE0991 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.900 |
Pcal_0133 | hisB | Pcal_0133 | Pcal_0139 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pai:PAE0990 imidazoleglycerol-phosphate dehydratase. | 0.999 |
Pcal_0133 | hisE | Pcal_0133 | Pcal_0135 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pai:PAE0986 phosphoribosyl-ATP pyrophosphohydrolase. | 0.874 |
Pcal_0133 | hisF | Pcal_0133 | Pcal_0137 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.921 |
Pcal_0133 | hisG | Pcal_0133 | Pcal_0134 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.986 |
Pcal_0133 | hisH | Pcal_0133 | Pcal_0130 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.940 |
Pcal_0133 | hisI | Pcal_0133 | Pcal_0131 | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.931 |
Pcal_0136 | Pcal_0089 | Pcal_0136 | Pcal_0089 | PFAM: histidinol dehydrogenase; KEGG: pai:PAE0988 histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0918 histidinol-phosphate aminotransferase. | 0.979 |
Pcal_0136 | Pcal_0133 | Pcal_0136 | Pcal_0133 | PFAM: histidinol dehydrogenase; KEGG: pai:PAE0988 histidinol dehydrogenase; Belongs to the histidinol dehydrogenase family. | PFAM: aminotransferase, class I and II; KEGG: pai:PAE0958 histidinol-phosphate aminotransferase. | 0.991 |