STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)    
Predicted Functional Partners:
Pcal_2058
PFAM: ATP-NAD/AcoX kinase; KEGG: pai:PAE0624 NAD+ kinase.
 
  
 0.960
Pcal_1625
Cytidyltransferase-related domain protein; KEGG: pai:PAE2259 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase.
 
  
 0.940
Pcal_0794
Cytidyltransferase-related domain protein; KEGG: pai:PAE1438 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase.
 
  
 0.939
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
    
 0.929
cobB-2
PFAM: Silent information regulator protein Sir2; KEGG: pai:PAE3500 NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily.
    
 0.929
Pcal_1118
PFAM: Quinolinate phosphoribosyl transferase; KEGG: pai:PAE2990 nicotinate phosphoribosyltransferase.
 
  
 0.813
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.784
Pcal_0792
PFAM: transcriptional regulator PadR family protein; KEGG: pai:PAE1218 hypothetical protein.
       0.777
Pcal_0791
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: sto:ST2084 hypothetical transcriptional regulator.
     
 0.688
Pcal_0790
PFAM: AzlC family protein; KEGG: csa:Csal_0390 AzlC-like protein.
       0.644
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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