STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pcal_1101ATPase, PilT family; PFAM: type II secretion system protein E; KEGG: pai:PAE3216 hypothetical protein. (517 aa)    
Predicted Functional Partners:
Pcal_1102
PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pai:PAE3217 hypothetical protein.
       0.774
cca
tRNA adenylyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
   
 0.588
Pcal_1100
PFAM: putative RNA methylase; THUMP domain protein; KEGG: pai:PAE3215 hypothetical protein.
       0.569
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
     0.519
adkA
KEGG: pai:PAE1681 adenylate kinase; Belongs to the archaeal adenylate kinase family.
  
     0.515
Pcal_0433
KEGG: pai:PAE3336 putative nucleotide binding protein.
  
   
 0.500
Pcal_2104
PFAM: Protein of unknown function DUF460; KEGG: pai:PAE0678 hypothetical protein.
  
     0.476
rps8e
TIGRFAM: ribosomal protein S8e; PFAM: ribosomal protein S8E; KEGG: pai:PAE3331 ribosomal protein S8.
  
     0.462
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.459
Pcal_0119
PFAM: protein of unknown function DUF99; KEGG: pai:PAE0952 conserved hypothetical protein; Belongs to the UPF0215 family.
  
   
 0.442
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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